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February 8, 2026International Journal of Molecular Sciences1 citationsOpen Access

Clinical Significance of Cytokeratin Fragments, Osteopontin, and HE4 in Pancreatic Adenocarcinoma

Clinical Significance of Cytokeratin 19-Fragments (CYFRA 21-1), Osteopontin (OPN) and Human Epididymis Protein 4 (HE4) in Pancreatic Adenocarcinoma

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Authors

ADAugustin Cătălin DimaDBDaniel Vasile BalabanISIulia-Ioana Stanescu-Spinu

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Overview

Cross-sectional study investigates biomarkers for pancreatic cancer diagnosis in a hospitalized population, suggesting limited predictive value.

Key Points

  • The study aims to evaluate the clinical significance of CYFRA 21-1, OPN, and HE4 in diagnosing pancreatic adenocarcinoma.
  • Single-center cross-sectional prospective study
  • Included sixty patients with pancreatic adenocarcinoma and fourteen controls
  • Biomarkers tested using Luminex x MAP technology
  • Correlational analysis of serum biomarkers
  • ROC curve analysis for diagnostic accuracy
  • Serum levels of CYFRA 21-1, OPN, and HE4 were evaluated, showing weak correlations among them
  • OPN levels were significantly higher in pancreatic cancer patients compared to controls
  • CA 19-9 displayed the highest diagnostic accuracy among the biomarkers
  • CYFRA 21-1 levels were higher in patients with significant weight loss before admission
  • OPN was not an independent predictor for pancreatic cancer in multivariate analysis.

Cite This Study

Dima et al. (2026) studied this question.

synapsesocial.com/papers/698828410fc35cd7a8847a26https://doi.org/10.3390/ijms27031562
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