Chemoselective Synthesis of α-Fluoromethyl Amides via the Controlled Addition of LiCH 2 F to N-Aryl and N-Alkyl Isocyanates

Key Points

• The aim is to develop a controlled method for synthesizing α-fluoroacetamides using lithium reagents.
• Utilized lithium fluoromethyl reagents for nucleophilic addition
• Performed under controlled conditions ensuring chemocontrol
• Preserved stereochemical information during synthesis
• Successfully synthesized α-fluoroacetamides through the new method
• Demonstrated full preservation of stereochemical information
• Achieved desired products with high specificity