What question did this study set out to answer?

The central aim is to develop a simple synthesis method for 2-anilino nicotinic acid derivatives using a specific catalyst.

February 8, 2026

Facile Synthesis of 2-Anilino Nicotinic Acids via Cu-Mg-Al LDO Catalysed Amination of 2-Chloronicotinic acid

AYAbhimanyu Kadedin Yadav SGShashikant S. Gholap PKParul KhuranaInstitute of Chemical Technology

Key Points

The central aim is to develop a simple synthesis method for 2-anilino nicotinic acid derivatives using a specific catalyst.
Utilized Cu-Mg-Al layered double hydroxides (LDO) as a catalyst for the reaction.
Conducted amination of 2-chloronicotinic acid with anilines.
Investigated various reaction conditions to optimize yield.
Successfully synthesized multiple 2-anilino nicotinic acid derivatives.
Reported high yields compared to conventional methods.
Demonstrated the catalyst's efficiency in fostering nucleophilic substitution.

Abstract

2-Anilino nicotinic acid derivatives represent an important class of heterocyclic compounds with diverse pharmacological activities. Conventional synthetic routes typically involve nucleophilic substitution of 2-chloronicotinic acid with aniline derivatives in presence...

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