Facile Synthesis of 2-Anilino Nicotinic Acids via Cu-Mg-Al LDO Catalysed Amination of 2-Chloronicotinic acid

Key Points

• The central aim is to develop a simple synthesis method for 2-anilino nicotinic acid derivatives using a specific catalyst.
• Utilized Cu-Mg-Al layered double hydroxides (LDO) as a catalyst for the reaction.
• Conducted amination of 2-chloronicotinic acid with anilines.
• Investigated various reaction conditions to optimize yield.
• Successfully synthesized multiple 2-anilino nicotinic acid derivatives.
• Reported high yields compared to conventional methods.
• Demonstrated the catalyst's efficiency in fostering nucleophilic substitution.

Abstract