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February 8, 2026New Journal of Chemistry3 citations

Facile Synthesis of 2-Anilino Nicotinic Acids via Cu-Mg-Al LDO Catalysed Amination of 2-Chloronicotinic acid

AYAbhimanyu Kadedin YadavSGShashikant S. GholapPKParul Khurana

Key Points

  • The central aim is to develop a simple synthesis method for 2-anilino nicotinic acid derivatives using a specific catalyst.
  • Utilized Cu-Mg-Al layered double hydroxides (LDO) as a catalyst for the reaction.
  • Conducted amination of 2-chloronicotinic acid with anilines.
  • Investigated various reaction conditions to optimize yield.
  • Successfully synthesized multiple 2-anilino nicotinic acid derivatives.
  • Reported high yields compared to conventional methods.
  • Demonstrated the catalyst's efficiency in fostering nucleophilic substitution.

Abstract

2-Anilino nicotinic acid derivatives represent an important class of heterocyclic compounds with diverse pharmacological activities. Conventional synthetic routes typically involve nucleophilic substitution of 2-chloronicotinic acid with aniline derivatives in presence...

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Cite This Study

Yadav et al. (2026) studied this question.

synapsesocial.com/papers/698828620fc35cd7a8847d89https://doi.org/10.1039/d5nj03368c
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