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Novel sensing method quantifies ochratoxin A using dendritic nanoparticles, suggesting reliable detection in food samples.
A novel polarity-switching photoelectrochemical (PEC) sensing method was proposed for quantifying ochratoxin A (OTA). Aminated dendritic mesoporous silica nanoparticle (DMSN) with well-defined pores was synthesized to encapsulate hemin, and its pore channels were sealed by OTA-specific aptamers as gatekeepers. Specific binding of OTA to the aptamer induced conformational changes and aptamer dissociation, triggering the release of entrapped hemin. The released hemin was captured by a hydrogen-bonded organic framework (HOF-101) modified electrode, which switched the photocurrent polarity from cathodic to anodic, with the anodic signal linearly increasing with OTA concentration. Under optimized conditions, the method exhibited a linear range of 10 pg mL⁻¹-10 μg mL⁻¹ and a limit of detection (LOD) of 3.5 pg mL⁻¹. Validated with camellia oil samples, its results were comparable to high-performance liquid chromatography (HPLC), verifying reliability for OTA detection in complex food matrices.
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Xiao et al. (2026) studied this question.
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