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The study aims to evaluate the antibody response to rubella vaccination in humans and baboons using ELISA and HAI tests.

February 8, 2026Open Access

Rubella IgM and IgG Following Rubella Vaccination in Humans and Baboons Measured by Enzyme Linked Immunosorbent Assays ([LISA)

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The study aims to evaluate the antibody response to rubella vaccination in humans and baboons using ELISA and HAI tests.
Vaccination of nine humans with rubella RA-27 vaccine.
Inoculation of three baboons with purified HPV-77 rubella vaccine.
Monitoring of IgM and IgG antibody levels through ELISA and HAI tests post-vaccination.
Rubella specific IgM levels were detected from 14 to 42 days post-vaccination.
IgG levels were observed after 28 days in all but one human vaccination.
Baboon IgM levels were elevated between day 9 and day 27, and IgG levels continuously after day 11.

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Vaccination generates rubella antibodies in humans and baboons, indicating a measurable immune response.

Mary Kay Tinker (1983) studied this question.

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