Amino acid derived chiral thioureas: design, synthesis and applications as NMR resolving agents for enantioselective recognition #

Ashutosh V. Bedekar; Raymond J. Butcher; Astha M. Dwivedi

doi:10.1039/d5ob02013a

January 1, 2025Organic & Biomolecular Chemistry

Amino acid derived chiral thioureas: design, synthesis and applications as NMR resolving agents for enantioselective recognition #

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Key Points

This research aims to develop chiral thiourea derivatives from amino acids and explore their applications in enantioselective recognition.
Designed chiral thiourea compounds using amino acid scaffolds.
Synthesized the derivatives through specific chemical reactions.
Evaluated their effectiveness as NMR resolving agents.
Chiral thioureas showed strong hydrogen bonding capabilities.
Demonstrated reliable enantioselective recognition in various applications.
Proved effective in enhancing the resolution of NMR spectra.

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Implication

New chiral thiourea derivatives demonstrate effective enantioselective recognition, suggesting promising applications in NMR analysis.

Abstract

A new class of chiral thiourea derivatives derived from amino acids has been developed that harness the dual influence of strong hydrogen bonding and stereogenic amino acid scaffolds. Both unsymmetrical...

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Bedekar et al. (2025) studied this question.

synapsesocial.com/papers/698828990fc35cd7a884838f https://doi.org/10.1039/d5ob02013a

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Amino acid derived chiral thioureas: design, synthesis and applications as NMR resolving agents for enantioselective recognition #

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Amino acid derived chiral thioureas: design, synthesis and applications as NMR resolving agents for enantioselective recognition #

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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