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Caffeine-derived N-heterocyclic carbenes demonstrate catalytic potential, suggesting new chemical applications.
Caffeine and other purine bases are naturally occurring, inexpensive, and readily available heterocycles composed of a fused imidazole–pyrimidine framework, whose five–membered imidazole core corresponds to a N–heterocyclic carbene (NHC) precursor....
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Reyes et al. (2026) studied this question.
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