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This research aims to explore the role of miR-127-3p in preeclampsia and its potential as a diagnostic marker.

Investigation on the clinical value and potential mechanism of miR-127-3p in preeclampsia

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Investigation finds miR-127-3p correlates with outcomes in preeclampsia, suggesting its potential as a diagnostic biomarker.

This research aims to explore the role of miR-127-3p in preeclampsia and its potential as a diagnostic marker.
Enrolled 113 preeclampsia patients and 93 healthy controls
Measured miR-127-3p levels using qPCR
Performed ROC analysis for diagnostic evaluation of miR-127-3p
Conducted in vitro experiments on HTR8/SVneo cells with hypoxia/reoxygenation treatment
Analyzed cell behavior and cytokine levels through CCK-8, Transwell, and ELISA
miR-127-3p was significantly down-regulated in preeclampsia patients
Significant correlation between miR-127-3p levels and severity of preeclampsia
miR-127-3p overexpression restored trophoblast cell function
miR-127-3p inhibited production of inflammatory cytokines
KIF3B identified as a downstream target of miR-127-3p

Xiong et al. (2026) studied this question.

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