Neuron-derived VIP via VIPR1 regulates intestinal epithelial differentiation, balances immune responses, and preserves gut barrier integrity by restraining secretory lineage expansion.
Neuron-derived VIP plays a crucial role in regulating intestinal epithelial function and preserving gut barrier integrity.
Absolute Event Rate: 0% vs 0%
Two studies in Nature Immunology by Jakob, Sterczyk et al. and Pirzgalska et al. show that neuron-derived vasoactive intestinal peptide (VIP) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its receptor VIPR1, VIP restrains secretory lineage expansion, balances type 1 and type 2 immunity, and establishes a neuro-epithelial circuit preserving gut barrier integrity.
Nabhani et al. (Tue,) reported a other. Neuron-derived VIP via VIPR1 regulates intestinal epithelial differentiation, balances immune responses, and preserves gut barrier integrity by restraining secretory lineage expansion.