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Synapse
February 8, 2026

An adaptive method of emergency department syndromic surveillance to nowcast the frequency of presentations that will have a severe 28-day outcome following influenza or COVID-19 infection: a retrospective analytical record linkage study.

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Authors

DMDavid J MuscatelloNRNectarios RoseKPKishor Kumar Paul

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Overview

A retrospective analytical study demonstrates improved prediction of severe outcomes in respiratory virus cases, suggesting better epidemic response strategies.

Key Points

  • The aim is to better predict the frequency of severe outcomes in influenza and COVID-19 cases using emergency department data.
  • Developed a retrospective record linkage study using emergency department data and infection outcomes from Australia.
  • Applied daily time series modelling with generalised additive models to estimate severe outcome frequencies.
  • Nowcasted severe outcomes with a focus on a 28-day period after infection.”],
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  • The mean daily nowcast error was 2.7 (34.2%) when predicting severe outcomes at day -4.
  • Using outcomes known at day -1 resulted in a higher mean error of 3.5 (43.8%).
  • The adaptive method could enhance real-time epidemic assessments for public health.

Cite This Study

Muscatello et al. (2026) studied this question.

synapsesocial.com/papers/698828d90fc35cd7a8848a79https://doi.org/10.1093/aje/kwag028
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