Incidence of New-Onset Cardiac Arrhythmias in Cocaine and Cannabis Users: A Retrospective Cohort Study

Abstract Background Cocaine use disorder prevalence is around 2.2% for individuals age 12 and older, with higher rates reaching 6.2% in young adults ages 18-25. In 2021 around 23% of all US overdose deaths were related to cocaine. Cannabis use disorder is more prevalent than cocaine use disorder with prevalence reaching 14.7%. This study aims to evaluate the impact of cocaine and cannabis on clinical cardiovascular outcomes. Specifically, it investigates the incidence of new-onset cardiac arrhythmia between the cocaine and cannabis users, as well as the incidence of cardiac arrest events, major adverse cardiovascular events including myocardial infarction (MI) and stroke, and all-cause mortality. Methods We did a retrospective cohort analysis using the TriNetX database of cocaine and cannabis users patients and created two cohorts: cocaine and cannabis. Propensity score matching was employed to reduce baseline disparities.The primary outcome was the incidence of new-onset cardiac arrhythmia. Secondary outcomes included cardiac arrest events, all cause mortality, and occurrence of major adverse cardiovascular events (MI and stroke). Results After matching, 248,769 patients were included in each cohort (cocaine and cannabis users). New-onset cardiac arrhythmia occurred more frequently in the cocaine group (0.2%) compared to the cannabis group (0.15%) (HR: 1.067; 95% CI: 1.022–1.115, P 0.035). Cocaine use was also associated with higher rates of the secondary outcomes: cardiac arrest (HR: 1.442; 95% CI: 1.346–1.545, P 0.001), all-cause mortality (HR: 1.215; 95% CI: 1.187–1.243, P 0.013), and major adverse cardiovascular events (HR: 1.147; 95% CI: 1.116–1.178, P 0.001). Conclusions Cocaine users experience significantly higher rates of new-onset cardiac arrhythmias, cardiac arrest, and major adverse cardiovascular events (MI and stroke) compared to cannabis users. These findings highlight the differing outcomes associated with substance use. Future research should aim to validate our findings through prospective, multicenter studies with standardized diagnostic methods as well as longer-term follow-up to more accurately define the outcomes.