The study demonstrates improved nasal drug delivery methods for brain targeting, indicating a need for safety validation.
Recent advances have expanded nasal delivery options, particularly for nose-to-brain targeting. Yet translation remains limited by insufficient validation, long-term safety uncertainties, and repeated-dose effects. Future progress requires balancing adhesion with penetration, robust toxicology, and integration of innovative polymers with optimized devices.
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Porfiryeva et al. (2026) studied this question.
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