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February 8, 2026European Heart Journal0 citations

Physical Activity Trends in Hypertrophic Cardiomyopathy Patients Using Accelerometry

Physical activity measured by accelerometry in hypertrophic cardiomyopathy: findings from the AFFECT-HCM study

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Why the study?

Recent guidelines advocate less stringent exercise restriction in hypertrophic cardiomyopathy, but the appropriate dosing of exercise remains debated.

Population

203 HCM patients and 37 G+/P- individuals

Comparison

HCM patients vs G+/P- individuals across phenotypes and NYHA classes

Design

Observational cross-sectional study

Follow-up

One week

Key result

HCM patients took 1319 fewer steps/day than controls; symptomatic and obese HCM had reduced activity, and each 250 steps/day increase raised quality of life by 2.15 points.

Authors

SSS A C SchoonveldePZP P ZwetslootAHAlexander Hirsch

Discussion

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Overview

Supports promoting activity in HCM; leaves open causal QoL benefits in prospective trials.

Key Points

  • The research aims to quantify physical activity in hypertrophic cardiomyopathy patients and relate findings to their phenotype and quality of life.
  • Participants wore an accelerometer for one week to measure daily steps and physical activity levels.
  • HCM patients were categorized based on phenotype and symptoms using the NYHA classification.
  • Quality of life was evaluated using the Kansas City Cardiomyopathy Questionnaire and EQ-5D-5L.
  • HCM patients took significantly fewer daily steps than G+/P- individuals (5254 vs 6573, p=0.005).
  • A larger percentage of HCM patients were sedentary (61%) compared to G+/P- individuals (35%, p=0.003).
  • Symptomatic HCM patients showed increased physical limitations compared to those who were asymptomatic and genotype-positive.

Structured PICO

P
Population
203 patients with hypertrophic cardiomyopathy (HCM) (mean age 59 years, 67% male) and 37 genotype-positive, phenotype-negative (G+/P-) individuals (mean age 48 years, 32% male).
C
Comparator
Genotype-positive, phenotype-negative (G+/P-) individuals
O
Outcome
Physical activity quantified by daily steps, sedentariness, time performing moderate-to-vigorous physical activity (MVPA %/day), and additional metabolic energy expenditure (AEE, kcal/kg/day) measured by accelerometer over one week

Patients with hypertrophic cardiomyopathy, particularly those who are symptomatic or obese, exhibit significantly reduced physical activity compared to genotype-positive/phenotype-negative individuals, and higher physical activity correlates with better quality of life.

Cite This Study

Schoonvelde et al. (2025) studied this question. HCM patients took 1319 fewer steps/day than controls; symptomatic and obese HCM had reduced activity, and each 250 steps/day increase raised quality of life by 2.15 points.

synapsesocial.com/papers/698828fd0fc35cd7a8848e45https://doi.org/10.1093/eurheartj/ehaf784.2598
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