Demonstrates the ability to utilize CSF for genomic analyses in pediatric patients, suggesting a novel approach to liquid biopsy.
This study demonstrates the feasibility of utilizing routinely discarded supernatants from CSF cytology specimens for LP-WGS and targeted NGS. Our approach optimizes the use of CSF that may be limited in pediatric patients as a source for liquid biopsy-based genomic studies. Future research will be necessary to optimize and validate the methodology to enable clinical implementation.
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Chun et al. (2026) studied this question.
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