Development and validation of a sample-to-result real time multiplex RT-PCR test for human African trypanosomiasis and arboviral febrile illnesses in the Democratic Republic of the Congo

Anne Hauner; Saidou Milua Lusala; Stijn Rogé; Nick Van Reet; Lieselotte Cnops; Raquel Inocencio Da Luz; Marjan Van Esbroeck; Merveille Kapandji; Meris Matondo Kuamfumu; Oscar N’lemvo Kiabanzawoko; Delphin Mavinga Phanzu; Paul Verlé; S. Ahuka-Mundeke; Kevin K. Ariën

doi:10.1186/s12879-026-12550-0

February 5, 2026BMC Infectious DiseasesOpen Access

Development and validation of a sample-to-result real time multiplex RT-PCR test for human African trypanosomiasis and arboviral febrile illnesses in the Democratic Republic of the Congo

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Key Points

To develop and validate a rapid diagnostic test for human African trypanosomiasis and arboviral febrile illnesses.
Created a real-time multiplex RT-PCR test.
Tested the diagnostic accuracy in samples from affected individuals.
Registered trial on ClinicalTrials.gov.
The multiplex RT-PCR test demonstrated high sensitivity and specificity.
Successful detection of both human African trypanosomiasis and arboviral infections was achieved.

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Implication

Validation of a diagnostic test for arboviral febrile illnesses in the Democratic Republic of the Congo, indicating its potential utility in clinical settings.

Abstract

Clinicaltrials.gov NCT04760678, registered on February 17th, 2021.

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Cite This Study

Hauner et al. (2026) studied this question.

synapsesocial.com/papers/6988292d0fc35cd7a88494b0 https://doi.org/10.1186/s12879-026-12550-0

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Development and validation of a sample-to-result real time multiplex RT-PCR test for human African trypanosomiasis and arboviral febrile illnesses in the Democratic Republic of the Congo

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Development and validation of a sample-to-result real time multiplex RT-PCR test for human African trypanosomiasis and arboviral febrile illnesses in the Democratic Republic of the Congo

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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