Key result
Higher serum aspartate and anabolic amino acids linked to better LVGLS in older women.
Why the study?
The authors sought to explore cellular biosynthesis and metabolism pathways to understand sex-based differences in myocardial aging and the relative preservation of LV systolic function in older women.
Are sex differences in cellular biosynthesis and metabolism pathways associated with left ventricular global longitudinal strain preservation in older adults?
Are sex differences in cellular biosynthesis and metabolism pathways associated with left ventricular global longitudinal strain preservation in older adults?
Sex differences in metabolism, specifically higher levels of certain amino acids in women, are linked to better preservation of left ventricular global longitudinal strain with aging.
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Wong et al. (2025) studied this question. Older women had better LV global longitudinal strain (-21.9% vs -20.1%, p=0.024) linked to higher serum aspartate and anabolic amino acids than men or women with poorer LVGLS.
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