Two cases demonstrate a double dissociation in phonological and graphemic processing, suggesting distinct pathways in the arcuate fasciculus.
We identified in two awake surgery cases a postoperative double dissociation between phonological and graphemic output buffer deficits. Using lesion‐symptom mapping from ischaemic mini‐strokes and preoperative tractography, we demonstrated that the phonological (resp. graphemic) disorder fitted with ventral (resp. dorsal) damage to the AF. Further studies are needed to confirm our hypothesis of a ventro‐dorsal functional organization within the AF for phonological versus graphemic processing.
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Mandonnet et al. (2026) studied this question.
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