Association of mitochondrial oxidative capacity with physical fitness in ageing: the Baltimore longitudinal study of ageing.

February 1, 2026

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Key Points

To investigate the relationship between mitochondrial oxidative capacity and physical fitness in ageing individuals.
Longitudinal study design based on the Baltimore Longitudinal Study of Ageing.
Assessment of mitochondrial oxidative phosphorylation capabilities.
Evaluation of cardiorespiratory fitness among participants.
Higher mitochondrial oxidative capacity is associated with better cardiorespiratory fitness.
The relationship is particularly notable in young and middle-aged adults.
Interindividual variability in fitness levels is influenced by mitochondrial function.

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Longitudinal Study Examines Link Between Oxidative Capacity and Fitness in Ageing Adults, Suggesting Its Importance.

Muscle mitochondrial OxPhos contributes to interindividual variability in cardiorespiratory fitness, especially in young and middle adulthood.

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Trevisan et al. (2026) studied this question.

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