Key result
Lower mitochondrial function was associated with higher perceived fatigability (0.47 points higher per 0.01/s lower kPCr, p=0.002), potentially mediated by higher anaerobic metabolism.
Why the study?
Poorer mitochondrial function is linked to age-related perceived fatigability, but whether glucose oxidation and anaerobic metabolism act as intermediate factors remains unclear.
Is poorer mitochondrial function associated with higher age-related perceived fatigability in adults?
Population
554 adults aged 22-99 years
Comparison
Mitochondrial function, glucose oxidation, and anaerobic metabolism levels
Design
Cross-sectional study
Authors
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Mitochondrial function may underlie age-related fatigability; leaves open causality and intervention effects in older adults.
Cross-Sectional (n=554)
Is poorer mitochondrial function associated with higher age-related perceived fatigability in adults?
Effect estimate: 0.47 points higher per 0.01/s lower kPCr
p-value: p=.002
Poorer mitochondrial function is associated with higher perceived fatigability, potentially mediated by higher glucose oxidation and anaerobic metabolism.
Liu et al. (2020) conducted a cross-sectional in Age-related perceived fatigability (n=554). Lower mitochondrial function (skeletal muscle oxidative capacity [kPCr]) vs. Higher mitochondrial function was evaluated on Perceived fatigability (rating of perceived exertion after a 5-minute treadmill walk) (0.47 points higher per 0.01/s lower kPCr, p=.002). Lower mitochondrial function was associated with higher perceived fatigability (0.47 points higher per 0.01/s lower kPCr, p=0.002), potentially mediated by higher anaerobic metabolism.
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