Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 9, 2026NeuroImageOpen Access

Morphometric dissimilarity in association cortices linked to autism subtype with more severe symptoms

View Full Paper
Ask AI
Bookmark
Share

Authors

HJHongxiu JiangMontreal Neurological Institute and HospitalRRRaul Rodriguez-CrucesMontreal Neurological Institute and HospitalKXKe XieMontreal Neurological Institute and Hospital

Discussion

Loading...

Member takes

Implication

Finds distinct neuroanatomical subtypes in autism, linking morphometric dissimilarity to symptom severity.

Key Points

  • To investigate the relationship between morphometric dissimilarity in association cortices and the severity of autism symptoms.
  • Estimated morphometric similarity networks (MSNs) from seven anatomical features in 348 ASD individuals and 452 typically developing controls.
  • Analyzed correlations between MSN values and severity of social and communication symptoms.
  • Identified three distinct subtypes of ASD based on MSN patterns.
  • The first principal component of MSN values showed a negative correlation with social and communication symptoms across ASD participants.
  • Subtype-1 displayed weaker morphometric similarity in frontotemporal regions and the most severe symptoms.
  • Subtype-2 had higher morphometric similarity values with less severe symptoms compared to subtype-1, while subtype-3 was comparable to TD and exhibited the least severe symptoms.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/698978dff0ec2af6756e718fhttps://doi.org/10.1016/j.neuroimage.2026.121775
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1On the evolution of polysensory superior temporal sulcus and middle temporal gyrus: A key component of the semantic system in the human brain2023 · 56 citations
  2. 2Hierarchical Cluster Analysis1966 · 327 citations
  3. 3A method for making group inferences from functional MRI data using independent component analysis2001 · 3,122 citations
  4. 4Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes2019 · 436 citations