Hippocampal volume trajectory and its relation to clinical course during and following ECT-treatment in patients with depression: A systematic review and meta-analysis

Key Points

• This research aims to explore the relationship between hippocampal volume changes and clinical outcomes in depression patients undergoing ECT.
• Conducted a systematic review of existing studies on ECT and hippocampal volume.
• Performed a meta-analysis to assess the effects on clinical outcomes.
• Included studies measuring hippocampal volume before and after ECT.
• Hippocampal volume increases following ECT were observed.
• These volume changes were temporary and did not correlate with changes in clinical symptoms of depression.