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February 1, 2026Journal of Affective DisordersOpen Access

Hippocampal volume trajectory and its relation to clinical course during and following ECT-treatment in patients with depression: A systematic review and meta-analysis

Tobias Bracht Lara Koehler Mario Pfammatter Niklaus Denier Leila M. Soravia Kristina Adorjan D Hubl Bogdan Draganski Sebastian Olbrich Annette Beatrix Brühl Gianluca Florineth

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Key Points

This research aims to explore the relationship between hippocampal volume changes and clinical outcomes in depression patients undergoing ECT.
Conducted a systematic review of existing studies on ECT and hippocampal volume.
Performed a meta-analysis to assess the effects on clinical outcomes.
Included studies measuring hippocampal volume before and after ECT.
Hippocampal volume increases following ECT were observed.
These volume changes were temporary and did not correlate with changes in clinical symptoms of depression.

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Implication

Systematic review finds no lasting link between hippocampal volume changes and depression course in patients undergoing ECT.

Abstract

Hippocampal volume increases following ECT are transient and not associated with the clinical course of depression.

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Cite This Study

Bracht et al. (2026) studied this question.

synapsesocial.com/papers/698978dff0ec2af6756e7216 https://doi.org/10.1016/j.jad.2026.121344

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