What question did this study set out to answer?

To evaluate the effectiveness of intrawound antibiotic prophylaxis combined with systemic antibiotics to prevent periprosthetic joint infection after total hip arthroplasty.

February 9, 2026Journal of Orthopaedic Surgery and ResearchOpen Access

Intrawound (local) antibiotic prophylaxis as an adjunct to systemic antibiotics to prevent periprosthetic joint infection (PJI) after total hip arthroplasty: a meta-analysis of cohort studies

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Authors

LZLihong ZhangWenzhou Medical University FZFan ZhangShandong University XXXiao‐Jun XuTianjin Tianhe Hospital

Discussion

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Implication

Meta-analysis shows potential reduction of periprosthetic joint infection in hip arthroplasty, suggesting refined approaches are needed.

Key Points

To evaluate the effectiveness of intrawound antibiotic prophylaxis combined with systemic antibiotics to prevent periprosthetic joint infection after total hip arthroplasty.
Meta-analysis of cohort studies
Comparison of intrawound and systemic antibiotic effects
Assessment of postoperative infection rates
Potential reduction in periprosthetic joint infection rates with intrawound antibiotics
Limited evidence for superficial surgical site infections
Need for standardized trials to optimize antibiotic regimens

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69897983f0ec2af6756e72ca https://doi.org/10.1186/s13018-026-06722-6

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Intrawound (local) antibiotic prophylaxis as an adjunct to systemic antibiotics to prevent periprosthetic joint infection (PJI) after total hip arthroplasty: a meta-analysis of cohort studies

Discussion

Member takes

Implication

Key Points

Cite This Study

Intrawound (local) antibiotic prophylaxis as an adjunct to systemic antibiotics to prevent periprosthetic joint infection (PJI) after total hip arthroplasty: a meta-analysis of cohort studies

Discussion

Member takes

Implication

Key Points

Cite This Study

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