Exopolysaccharides of Streptococcus mutans Enhance Oral Colonisation and Drug Tolerance in Helicobacter pylori

Yujia Hao; Yuqiu Huang; Ruonan Chen; Yuqing Li; Xiaojing Huang

doi:10.1016/j.identj.2026.109405

February 5, 2026International Dental JournalOpen Access

Exopolysaccharides of Streptococcus mutans Enhance Oral Colonisation and Drug Tolerance in Helicobacter pylori

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Key Points

The aim is to understand how exopolysaccharides (EPS) from Streptococcus mutans influence Helicobacter pylori colonization and antibiotic tolerance.
Analyzed the role of S. mutans biofilms in oral H. pylori adhesion and colonization.
Investigated Gtf-driven biosynthesis of EPS by S. mutans.
Assessed the impact of EPS on antibiotic tolerance in H. pylori.
S. mutans biofilms significantly enhance the colonization of H. pylori in oral environments.
The presence of EPS correlates with increased tolerance of H. pylori to antibiotics.

Implication

Demonstrates enhanced colonization and drug tolerance in Helicobacter pylori due to exopolysaccharides from Streptococcus mutans, suggesting a link between oral bacteria and gastric health.

Abstract

S. mutans biofilms mediate the adhesion, colonisation, and antibiotic tolerance of oral H. pylori via Gtf-driven EPS biosynthesis.

Discussion

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Cite This Study

Hao et al. (2026) studied this question.

synapsesocial.com/papers/69897983f0ec2af6756e736d https://doi.org/10.1016/j.identj.2026.109405

View Full Paper

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Exopolysaccharides of Streptococcus mutans Enhance Oral Colonisation and Drug Tolerance in Helicobacter pylori

Key Points

Implication

Abstract

Discussion

Cite This Study

Exopolysaccharides of Streptococcus mutans Enhance Oral Colonisation and Drug Tolerance in Helicobacter pylori

Key Points

Implication

Abstract

Discussion

Cite This Study

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