What question did this study set out to answer?

To evaluate the effectiveness of cyclosporine (CsA) as a treatment for steroid-resistant nephrotic syndrome (INS).

Treatment of steroid-resistant nephrotic syndrome with cyclosporine: Study of 17 cases and a literature review

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Retrospective cohort study evaluates CsA's effectiveness in reducing proteinuria in steroid-resistant nephrotic syndrome.

To evaluate the effectiveness of cyclosporine (CsA) as a treatment for steroid-resistant nephrotic syndrome (INS).
Conducted a retrospective cohort study on 17 steroid-resistant INS patients.
Evaluated pre- and post-treatment laboratory data regarding proteinuria levels.
Performed a literature review on the treatment of steroid-resistant INS with CsA.
Mean 24-hr proteinuria decreased significantly from 3181 mg to 915 mg after CsA treatment (p<0.001).
Remission was achieved in 70.5% of patients, with 52.9% obtaining complete remission.
Adverse effects included nephrotoxicity (11.7%) and hypertrichosis (5.8%), among others.

Fernandes et al. (2005) studied this question.

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