PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
February 9, 2026Proceedings of the National Academy of SciencesOpen Access

HSCs/MPPs as cells of origin with altered differentiation hierarchy impairing immunomicroenvironment in PML::RARA and CBFα/β fusion AML

View Full Paper
Ask AI
Bookmark
Share

Authors

NQNiu QiaoZWZixuan WangYZYu-Liang Zhang

Discussion

Loading...

Member takes

Overview

Investigates altered differentiation in leukemia stem cells, affecting immune function in acute myeloid leukemia subtypes, highlighting crucial therapeutic implications.

Key Points

  • The research aims to explore how leukemia stem cells influence immune cells and differentiation hierarchies in acute myeloid leukemia.
  • Utilized single-cell RNA sequencing to analyze AML subtypes
  • Examined fusion transcription factor expression in leukemia and immune cells
  • Conducted DNA-FISH to confirm fTF presence in various cell types
  • Developed a ligand-receptor risk-scoring model for prognostics
  • Fusion transcription factors are expressed in leukemia blasts and immune cells
  • Evidence of altered immune cell communication networks linked to fTF expression
  • Identified necessity to target LSCs for effective long-term remission in AML patients

Cite This Study

Qiao et al. (2026) studied this question.

synapsesocial.com/papers/698979b9f0ec2af6756e7909https://doi.org/10.1073/pnas.2526334123
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fusion Gene Depletion Eliminates Stemness and Induces Bidirectional Differentiation of Acute Myeloid Leukemia2025
  2. 2Characterizing the impact of MLL fusion variants and fusion partners on leukemia plasticity using a human CRISPR-engineered MLL-rearranged leukemia model2026 · 1 citations
  3. 3Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth2024 · 24 citations
  4. 4Dynamics of leukemic blast and immune cell populations in Acute Myeloid Leukemia2025
  5. 5Single-cell multi-omics uncovers differentiation-dependent transcriptional programs shaping epigenetic subgroups in AML2025