What question did this study set out to answer?

To explore the effectiveness of 68Ga-DOTA-TATE PET/CT in evaluating hypertrophic pachymeningitis.

February 9, 2026Clinical Nuclear Medicine0 citations

68GA-DOTA-TATE PET/CT in the Assessment of Cranial and Spinal Hypertrophic Pachymeningitis

EIEmine Goknur IsikIstanbul University ETEdanur Topal MBMehmet BarbüroğluFatih University

Key Points

To explore the effectiveness of 68Ga-DOTA-TATE PET/CT in evaluating hypertrophic pachymeningitis.
Conducted imaging using 68Ga-DOTA-TATE PET/CT and MRI on a patient suspected of having pachymeningitis.
Assessed the correlation between radiotracer uptake and dural thickening seen in MRI.
The PET/CT scan showed intense radiotracer uptake in the areas corresponding to dural thickening.
Findings indicate the potential for somatostatin receptor imaging to evaluate disease activity and extent.
The method could help differentiate between inflammatory and non-inflammatory conditions affecting the dura.

Abstract

Hypertrophic pachymeningitis is an uncommon disorder characterized by chronic inflammation and thickening of the dura mater, which can be idiopathic or secondary to autoimmune or infectious causes such as sarcoidosis, IgG4-related disease, tuberculosis, or syphilis. We report the case of a patient with a preliminary diagnosis of pachymeningitis in whom 68 Ga-DOTA-TATE PET/CT demonstrated intense radiotracer uptake corresponding to dural thickening on MRI. The findings suggest the potential role of somatostatin receptor imaging in assessing disease extent and activity, and in differentiating inflammatory pachymeningitis from neoplastic or infectious mimics.

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