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February 9, 2026Journal of Nephrology

Evaluation of aortic arch calcification in hemodialysis patients

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Why the study?

Aortic arch calcification is related to cardiovascular disease in the general population and vascular calcifications are common in dialysis patients, but the risk factors associated with aortic arch calcification in stable hemodialysis patients required evaluation.

Population

132 stable hemodialysis patients

Comparison

Patients with aortic arch calcification vs without aortic arch calcification

Design

Retrospective study

Key result

Aortic arch calcification was present in 51% of hemodialysis patients and was independently associated with age (OR 1.069), RRT duration (OR 1.02), calcium-phosphate product (OR 1.03), systolic BP (OR

Authors

FFFabio FabbianCCCarlos E. CatalanoOOrlandi

Discussion

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Overview

AAC prevalence and risk factor associations in hemodialysis warrant prospective outcome studies; leaves open whether modification alters events or should guide care.

Key Points

  • This study aims to evaluate risk factors associated with aortic arch calcification (AAC) in hemodialysis patients.
  • Retrospective analysis of 132 stable hemodialysis patients' chest radiographs
  • Comparison of clinical characteristics between patients with and without AAC
  • Logistic regression to identify independent predictors of AAC
  • AAC detected in 51% of patients
  • Older patients and those on renal replacement therapy longer had higher prevalence of AAC
  • Independent predictors of AAC include age, duration on renal replacement therapy, calcium-phosphate product, systolic blood pressure, and peripheral vascular disease.

Structured PICO

P
Population
Stable hemodialysis patients (mean age 65 ± 12 yrs)
O
Outcome
Risk factors associated with aortic arch calcification (AAC)surrogate

In stable hemodialysis patients, aortic arch calcification is independently associated with age, duration of renal replacement therapy, calcium-phosphate product, systolic blood pressure, and peripheral vascular disease.

Cite This Study

Fabbian et al. (2005) studied this question. Aortic arch calcification was present in 51% of hemodialysis patients and was independently associated with age (OR 1.069), RRT duration (OR 1.02), calcium-phosphate product (OR 1.03), systolic BP (OR.

synapsesocial.com/papers/698979d9f0ec2af6756e7c7bhttps://doi.org/10.1093/joneph/18.3.289
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