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October 15, 2015Chinese Medical JournalOpen Access

Aortic Artery and Cardiac Valve Calcification are Associated with Mortality in Chinese Hemodialysis Patients

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Why the study?

Does the presence of aortic artery calcification or cardiac valve calcification predict mortality in maintenance hemodialysis patients?

Population

110 maintenance hemodialysis patients in Shanghai Ruijin Hospital, China. Mean age 55.2 ± 1.4 years, 58.2%…

Comparison

Presence of aortic artery calcification detected… vs Absence of aortic artery calcification or…

Design

Cohort

Follow-up

42 months

Key result

The presence of aortic artery calcification was independently associated with an increased risk of all-cause mortality (HR 3.149) in maintenance hemodialysis patients.

Authors

XCXiaonong ChenZCZi-Jin ChenXMXiaobo Ma

Discussion

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Overview

May flag higher-risk hemodialysis patients for monitoring; leaves open whether modifying calcification improves outcomes.

Study Design

Type

Cohort (n=110)

Multicenter

No

Structured PICO

Does the presence of aortic artery calcification or cardiac valve calcification predict mortality in maintenance hemodialysis patients?

P
Population
110 adult maintenance hemodialysis patients in China were followed for 42 months to assess the association of aortic artery and cardiac valve calcification with mortality.
E
Exposure
Presence of aortic artery calcification (AAC) detected by lateral lumbar X-ray plain radiography or cardiac valve calcification (CVC) detected by echocardiography
C
Comparator
Absence of aortic artery calcification (AAC) or cardiac valve calcification (CVC)
O
Outcome
All-cause mortality and cardiovascular mortality at 42 months follow-uphard clinical

Main Result

Hazard Ratio: 3.149 (95% CI 0.889–11.159)

p-value: p=0.025

Lateral lumbar X-ray and echocardiography are simple methods to detect aortic and cardiac valve calcification, which independently predict all-cause and cardiovascular mortality in maintenance hemodialysis patients.

Limitations

  • Evaluation of AAC used a semi-quantitative method, which may underestimate true calcium deposition
  • Small population size
  • Short-term follow-up (42 months)
  • Semi-quantitative method for evaluating AAC may underestimate true calcium deposition

Cite This Study

Chen et al. (2015) conducted a cohort in Maintenance hemodialysis (n=110). Aortic artery calcification (AAC) vs. Absence of AAC was evaluated on All-cause mortality (HR 3.149, 95% CI 0.889-11.159, p=0.025). The presence of aortic artery calcification was independently associated with an increased risk of all-cause mortality (HR 3.149) in maintenance hemodialysis patients.

synapsesocial.com/papers/6a775936df493903fd1edac1https://doi.org/10.4103/0366-6999.167315
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