Key result
Baseline cardiac valvular calcification predicts ~114% higher all-cause mortality in incident haemodialysis patients.
Why the study?
Cardiac valvular calcification is prevalent in haemodialysis patients, but its association with mortality in Chinese incident haemodialysis patients remains unknown.
Does the presence of cardiac valvular calcification predict all-cause mortality in Chinese incident haemodialysis patients?
Cohort (n=224)
No
Does the presence of cardiac valvular calcification predict all-cause mortality in Chinese incident haemodialysis patients?
Cardiac valvular calcification at baseline is an independent risk factor for all-cause mortality in incident haemodialysis patients, supporting the use of baseline echocardiography.
Valvular calcification may aid prognostication in incident haemodialysis; hypothesis-generating for echocardiography-guided interventions.
BACKGROUND: Cardiac valvular calcification (CVC) is prevalent in haemodialysis (HD) patients. Its association with mortality in Chinese incident haemodialysis (IHD) patients remains unknown. METHODS: A total of 224 IHD patients who had just begun HD therapy at Zhongshan Hospital, Fudan University, were enrolled and divided into two groups according to the detection of cardiac valvular calcification (CVC) by echocardiography. The patients were followed for a median of 4 years for all-cause mortality and cardiovascular mortality. RESULTS: During follow-up, 56 (25.0%) patients died, including 29 (51.8%) of cardiovascular disease. The adjusted HR related to all-cause mortality was 2.14 (95% CI, 1.05-4.39) for patients with cardiac valvular calcification. However, CVC was not an independent risk factor for cardiovascular mortality in patients who had just begun HD therapy. CONCLUSION: CVC at baseline is an independent risk factor for all-cause mortality in HD patients and makes an independent contribution to the prediction of all-cause mortality. These findings support the use of echocardiography at the beginning of HD.
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Cheng et al. (2023) conducted a cohort in Incident haemodialysis (n=224). Cardiac valvular calcification vs. No cardiac valvular calcification was evaluated on All-cause mortality (HR 2.14, 95% CI 1.05-4.39, p=<0.05). Cardiac valvular calcification at baseline independently predicted all-cause mortality in incident haemodialysis patients (adjusted HR 2.14).
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