Dysregulation of Transient Receptor Potential Cation Channels and Epithelial-to-Mesenchymal Transition-Related Genes in Fuchs Endothelial Corneal Dystrophy: A Bioinformatics Approach.

Key Points

• To examine the roles of TRP cation channels and genes involved in epithelial-to-mesenchymal transition in Fuchs endothelial corneal dystrophy.
• Analyzed gene expression profiles using bioinformatics tools.
• Identified pathways linked to cellular senescence and cell death.
• Examined the role of apoptotic regulators in corneal endothelial cells.
• TRP cation channels showed significant dysregulation.
• Altered apoptotic regulators were found, linked to endothelial cell death.
• Identified pathways that may serve as treatment targets for FECD.