Dysregulation of Transient Receptor Potential Cation Channels and Epithelial-to-Mesenchymal Transition-Related Genes in Fuchs Endothelial Corneal Dystrophy: A Bioinformatics Approach.

Kiran Bharat Gaikwad; Harshavardhan Bv; Janakiraman Narayanan; Prema Padmanabhan; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; FE Kruse; Taichi Yuasa; Noriko Koizumi; Naoki Okumura; Abhijit Majumder; Sailaja Elchuri; Sandeep Kumar

doi:10.1097/ico.0000000000004099

February 4, 2026

Dysregulation of Transient Receptor Potential Cation Channels and Epithelial-to-Mesenchymal Transition-Related Genes in Fuchs Endothelial Corneal Dystrophy: A Bioinformatics Approach.

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Key Points

To examine the roles of TRP cation channels and genes involved in epithelial-to-mesenchymal transition in Fuchs endothelial corneal dystrophy.
Analyzed gene expression profiles using bioinformatics tools.
Identified pathways linked to cellular senescence and cell death.
Examined the role of apoptotic regulators in corneal endothelial cells.
TRP cation channels showed significant dysregulation.
Altered apoptotic regulators were found, linked to endothelial cell death.
Identified pathways that may serve as treatment targets for FECD.

Implication

This bioinformatics study identifies gene dysregulation in Fuchs endothelial corneal dystrophy, suggesting new treatment targets.

Abstract

Dysregulated TRP cation channels contribute to cellular senescence and peripheral sensitization in FECD, whereas altered apoptotic regulators drive corneal endothelial cell death. Most likely, these pathways represent potential targets for treatment of patients with FECD.

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Cite This Study

Gaikwad et al. (2026) studied this question.

synapsesocial.com/papers/698979d9f0ec2af6756e7d51 https://doi.org/10.1097/ico.0000000000004099

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Dysregulation of Transient Receptor Potential Cation Channels and Epithelial-to-Mesenchymal Transition-Related Genes in Fuchs Endothelial Corneal Dystrophy: A Bioinformatics Approach.

Key Points

Implication

Abstract

Discussion

Cite This Study

Dysregulation of Transient Receptor Potential Cation Channels and Epithelial-to-Mesenchymal Transition-Related Genes in Fuchs Endothelial Corneal Dystrophy: A Bioinformatics Approach.

Key Points

Implication

Abstract

Discussion

Cite This Study

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