PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 9, 20260 citations

Neurofilament Light Chain in Fibromyalgia: Correlation With Central and Peripheral Nervous System Dysfunction.

View Full Paper
MRMaddalena RuggieriCGConcetta Domenica GarganoGPGiulia Paparella

Key Points

  • This research aims to explore the relationship between neurofilament light chain levels and nervous system dysfunction in fibromyalgia.
  • Measured serum levels of neurofilament light chain (NfL) in individuals with fibromyalgia.
  • Assessed central and peripheral nervous system function.
  • Evaluated correlation between NfL levels and signs of neuronal stress.
  • Higher levels of neurofilament light chain were found in individuals with fibromyalgia.
  • The study identified a correlation between NfL levels and indicators of nervous system dysfunction.
  • NfL is suggested as a potential biomarker for chronic pain but lacks specificity for certain types of nerve damage.

Abstract

These findings support the concept of FM as a neurogenic disorder and suggest serum NfL as a potential biomarker of neuronal stress in chronic pain, although it is not specific for peripheral nerve damage or cognitive dysfunction.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Ruggieri et al. (2026) studied this question.

synapsesocial.com/papers/698979d9f0ec2af6756e7e58https://doi.org/10.1002/ejp.70228
Ask AI
Helpful
Bookmark
Share
View Full Paper