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February 9, 2026

Bleomycin Electrosclerotherapy and Skin Hyperpigmentation in Slow-flow Vascular Malformations: A Retrospective Monocentric Analysis.

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Authors

JLJulius Henry LoeserDSD SchrammBCBeatrix Cucuruz

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Overview

Retrospective analysis shows higher skin hyperpigmentation risk after bleomycin electrosclerotherapy, indicating important factors for treatment.

Key Points

  • This analysis aims to investigate the occurrence of skin hyperpigmentation after bleomycin electrosclerotherapy in slow-flow vascular malformations.
  • Retrospective study at an interdisciplinary vascular anomalies center
  • Analyzed 80 procedures in 72 patients over 21 months
  • Documented skin hyperpigmentation clinically and photographically
  • Exploratory threshold analyses performed at doses of 0.10 and 0.15 mg/kg
  • Compared findings with recent publications on hyperpigmentation after bleomycin administration.
  • Skin hyperpigmentation occurred in 4 of 7 lymphatic malformations and 20 of 44 venous malformations.
  • Higher incidence with the hexagonal electrode (58.9%) compared to others.
  • Intravenous administration resulted in more hyperpigmentation (61.8%) than intralesional (41.3%).
  • A threshold dose of ≥0.10 mg/kg showed a higher risk ratio (RR 2.30, 95% CI 1.27-4.15) for hyperpigmentation.

Cite This Study

Loeser et al. (2026) studied this question.

synapsesocial.com/papers/69897a06f0ec2af6756e8306https://doi.org/10.1055/a-2783-4420
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