Findings reveal age-related impairment of corneal sensitivity and reflex tearing in congenital aniridia, suggesting significant underlying mechanisms.
These findings suggest impaired mechano-nociceptors, polymodal nociceptors, and cold thermoreceptors function in congenital aniridia, with severity increasing with age and AAK grade. LOF mutation results show a trend with greater deficits than reduced expression variants, highlighting a critical role of PAX6 in corneal sensory integrity.
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Acosta et al. (2026) studied this question.
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