MID/QC Applied Substrate Series 24 - Reaction Steering Through Substrate Geometry: Coherence Pockets, Torsional Gating, and Directional Bias

This paper reframes reaction control within the MID/QC substrate framework, showing that true reaction steering arises from geometric orchestration rather than probabilistic modulation. It introduces coherence pockets, torsional gating, and directional bias as substrate-driven mechanisms that guide reaction pathways, stabilize transitional configurations, and suppress unwanted outcomes. The manuscript unifies catalytic control, enzymatic specificity, and reaction design under a substrate-first model, establishing geometry as the primary interface for reaction steering.