Progranulin impairs efferocytosis of macrophages in renal fibrosis by negatively regulating PPAR-δ-mediated inhibition of the JAK-STAT signaling pathway

Yang Zhao; Weichao Tu; Y. Liu; Xiaoqian Yang; Yueyan Li; Hao Yan

doi:10.1007/s00018-026-06099-z

February 7, 2026Cellular and Molecular Life SciencesOpen Access

Progranulin impairs efferocytosis of macrophages in renal fibrosis by negatively regulating PPAR-δ-mediated inhibition of the JAK-STAT signaling pathway

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Key Points

The study aims to investigate the role of progranulin in impairing macrophage efferocytosis during renal fibrosis.
Examined the interaction between progranulin and PPAR-δ.
Analyzed the effects on STAT1/2 signaling in macrophages.
Evaluated macrophage clearance of apoptotic cells in renal fibrosis contexts.
Progranulin binding to PPAR-δ was confirmed.
Activation of the STAT1/2 signaling pathway was observed.
Impaired clearance of apoptotic cells due to inhibited macrophage efferocytosis was demonstrated.

Implication

This research shows how progranulin disrupts macrophage efferocytosis in renal fibrosis, suggesting new therapeutic targets.

Abstract

PGRN inhibits macrophage efferocytosis during renal fibrosis by binding and inhibiting PPAR-δ, thereby activating the STAT1/2 signaling pathway and impairing the clearance of apoptotic cells.

Discussion

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69897a35f0ec2af6756e894c https://doi.org/10.1007/s00018-026-06099-z

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Progranulin impairs efferocytosis of macrophages in renal fibrosis by negatively regulating PPAR-δ-mediated inhibition of the JAK-STAT signaling pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

Progranulin impairs efferocytosis of macrophages in renal fibrosis by negatively regulating PPAR-δ-mediated inhibition of the JAK-STAT signaling pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

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