Research demonstrates how progranulin reduces neuronal ferroptosis in cerebral ischemia-reperfusion injury, suggesting new treatment options.
In summary, PGRN protected neurons from the cerebral I/R injury-induced ferroptosis via activating p-STAT3/HSPA5 signaling. Therefore, PGRN may be a therapeutic target for cerebral I/R injury.
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Su et al. (2026) studied this question.
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