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February 9, 2026Analytical Chemistry

Direct, Pretreatment-Free Surface-Enhanced Raman Scattering (SERS) Detection of Uric Acid in Urine Facilitated by Efficient Hydrogen Bonding-Driven Capture

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Authors

SASupriya AttaTVTuan Vo-Dinh

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Overview

Demonstrates a new method for detecting uric acid in urine, suggesting advances in noninvasive diagnostics.

Key Points

  • The central aim is to develop a sensitive and rapid method for detecting uric acid in urine without pretreatment.
  • Utilized bimetallic gold-silver nanostars functionalized with sodium dodecyl sulfate (BGNS@SDS)
  • Implemented a separation-free 'mix-and-detect' method for SERS detection
  • Conducted density functional theory (DFT) analysis to confirm uric acid capture under alkaline conditions
  • Tested detection limits in both water and spiked artificial urine samples
  • Quantified uric acid in urine samples from ten healthy volunteers
  • Achieved detection limits of 2.2 μg/mL in water and 3 μg/mL in artificial urine samples
  • Limits are significantly lower than the pathological threshold of approximately 750 μg/mL
  • Successfully differentiated uric acid levels between healthy individuals and those at risk in urine samples
  • The SERS platform shows potential for rapid, point-of-care diagnostics for low-affinity biomarkers

Cite This Study

Atta et al. (2026) studied this question.

synapsesocial.com/papers/69897a35f0ec2af6756e8997https://doi.org/10.1021/acs.analchem.5c06098
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