Electrochemically Enabled C7 Functionalization of Quinolines from o-Propynolanilines: Divergent Access to 4,7-Dichloro and 4-Chloro-7-alkyl (aryl) Quinolines

Key Points

• To develop an electrochemical method for regioselective C7 functionalization of quinolines.
• Utilized electrochemical techniques to modify o-propynolanilines.
• Focused on divergent synthesis of 4,7-dichloro and 4-chloro-7-alkyl (aryl) quinolines.
• Examined the efficacy of the method in overcoming electronic deactivation.
• Successfully achieved regioselective functionalization at the C7 position of quinolines.
• Demonstrated the ability to synthesize multiple quinoline derivatives through the proposed method.
• Showed increased yields compared to traditional methods, enhancing synthetic accessibility.