Isorhynchophylline protects against ferroptosis in diabetic nephropathy by activating Nrf2

Ting Yu; Fengling Chen; Bing You; Xiaopan Zhang; Yilin Wang; Ying Huang; Xiang Shao; Bo Sun

doi:10.1016/j.nefroe.2026.501408

January 1, 2026Nefrología (English Edition)Open Access

Isorhynchophylline protects against ferroptosis in diabetic nephropathy by activating Nrf2

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Key Points

The study investigates how isorhynchophylline protects against ferroptosis in diabetic nephropathy.
Examined the effects of isorhynchophylline on renal cells under diabetic conditions.
Evaluated the activation of the Nrf2/HO-1 signaling pathway.
Assessed ferroptosis markers in renal tissues.
Isorhynchophylline significantly reduced markers of ferroptosis in diabetic nephropathy.
Activation of the Nrf2/HO-1 pathway was evidenced.
Potential therapeutic benefits for diabetic nephropathy were indicated.

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Implication

Findings reveal isorhynchophylline suppresses ferroptosis in diabetic nephropathy, suggesting its therapeutic promise.

Abstract

IRN plays a renoprotective role in DN by suppressing ferroptosis, which might be ascribed to the Nrf2/HO-1 pathway activation, highlighting the potential therapeutic application of IRN for DN treatment.

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Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/698acaad7c832249c30b9f6a https://doi.org/10.1016/j.nefroe.2026.501408

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Isorhynchophylline protects against ferroptosis in diabetic nephropathy by activating Nrf2

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Isorhynchophylline protects against ferroptosis in diabetic nephropathy by activating Nrf2

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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