Isorhamnetin Protects Against Organophosphate-Induced Cardiac Damage in Wistar Rats Through Redox Balance and Nrf2/HO-1 Signalling.

Q: What does this research mean for the field?

Isorhamnetin protects against organophosphate-induced cardiac damage in Wistar rats by restoring redox balance and modulating Nrf2/HO-1 signalling. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yousra Bseiso; Badriyah S. Alotaibi; Alaa A A Aljabali; Omar Gammoh; Muna Oqal; Mohammad. E. Rabeh; AHMAD MUZAKKI RABI; Esam Qnais; Abdelrahim Alqudah

doi:10.1111/bcpt.70197

April 1, 2026

Isorhamnetin Protects Against Organophosphate-Induced Cardiac Damage in Wistar Rats Through Redox Balance and Nrf2/HO-1 Signalling.

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Key Points

The research aims to evaluate the protective effects of isorhamnetin against cardiac damage caused by organophosphates.
Administered isorhamnetin to Wistar rats exposed to organophosphates.
Assessed redox balance in cardiac tissue.
Measured inflammatory and apoptotic marker levels.
Evaluated activation of Nrf2 and HO-1 signalling pathways.
Isorhamnetin significantly restored redox balance in cardiac tissue.
Reduced levels of inflammatory and apoptotic markers were observed.
Activation of Nrf2/HO-1 signalling was enhanced after treatment.

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Implication

Demonstrates how isorhamnetin protects cardiac health from organophosphate damage, indicating a potential therapeutic approach.

Abstract

Isorhamnetin alleviates CPF-induced cardiotoxicity by restoring redox balance and modulating inflammatory and apoptotic pathways through Nrf2/HO-1 signalling.

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Cite This Study

Bseiso et al. (2026) studied this question.

synapsesocial.com/papers/69a1359eed1d949a99abfab8 https://doi.org/10.1111/bcpt.70197

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Isorhamnetin Protects Against Organophosphate-Induced Cardiac Damage in Wistar Rats Through Redox Balance and Nrf2/HO-1 Signalling.

Key Points

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Implication

Abstract

Discussion

Cite This Study

Isorhamnetin Protects Against Organophosphate-Induced Cardiac Damage in Wistar Rats Through Redox Balance and Nrf2/HO-1 Signalling.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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