The research aims to evaluate the protective effects of isorhamnetin against cardiac damage caused by organophosphates.
Administered isorhamnetin to Wistar rats exposed to organophosphates.
Assessed redox balance in cardiac tissue.
Measured inflammatory and apoptotic marker levels.
Evaluated activation of Nrf2 and HO-1 signalling pathways.
Isorhamnetin significantly restored redox balance in cardiac tissue.
Reduced levels of inflammatory and apoptotic markers were observed.
Activation of Nrf2/HO-1 signalling was enhanced after treatment.
Abstract
Isorhamnetin alleviates CPF-induced cardiotoxicity by restoring redox balance and modulating inflammatory and apoptotic pathways through Nrf2/HO-1 signalling.