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February 10, 2026Nature CommunicationsOpen Access

Interleukin-10 expressing B lineage cells in visceral adipose tissue protect against aging-related insulin resistance and extend lifespan

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JGJielong GuoPeking University XHXue HanChinese Academy of Medical Sciences & Peking Union Medical College YQYue QinChina Agricultural University

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Implication

Findings reveal that interleukin-10 expressing B lineage cells alleviate insulin resistance in older individuals, suggesting potential therapeutic pathways.

Key Points

This research aims to investigate the role of interleukin-10 expressing B lineage cells in visceral adipose tissue on aging-related insulin resistance and lifespan extension.
Analyzed visceral adipose tissue samples from aged humans and mice.
Conducted B cell-specific knockout studies to assess IL-10's role in inflammation and insulin resistance.
Performed adoptive transfer experiments with B-10 cells from wild-type mice to evaluate their impact on aging-related conditions.
Monitored changes in BAFF levels and their influence on B-10 cell proliferation in aged VAT.
B-10 cells are significantly increased in aged visceral adipose tissue and are the main source of IL-10.
Knockout of IL-10 in B cells led to increased inflammation and insulin resistance, shortening lifespan.
Adoptive transfer of wild-type B-10 cells partially reversed inflammation and insulin resistance in aged models.
BAFF levels in VAT were found to promote B-10 cell proliferation, while knock-down reduced their expansion.

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/698acaad7c832249c30ba01e https://doi.org/10.1038/s41467-026-69371-7

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Implication

Findings reveal that interleukin-10 expressing B lineage cells alleviate insulin resistance in older individuals, suggesting potential therapeutic pathways.

Interleukin-10 expressing B lineage cells in visceral adipose tissue protect against aging-related insulin resistance and extend lifespan

Discussion

Member takes

Implication

Key Points

Cite This Study

Interleukin-10 expressing B lineage cells in visceral adipose tissue protect against aging-related insulin resistance and extend lifespan

Discussion

Member takes

Implication

Key Points

Cite This Study

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