What question did this study set out to answer?

The aim is to analyze currently available anti-obesity medications and explore emerging pharmacotherapy directions.

Drugs Used in the Treatment of Obesity – A Systematic Review

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A systematic review analyzes anti-obesity medications and their effectiveness in treating obesity, suggesting future pathways.

The aim is to analyze currently available anti-obesity medications and explore emerging pharmacotherapy directions.
Literature review of anti-obesity medications
Evaluation of five major drug groups: orlistat, naltrexone-bupropion, phentermine, GLP-1 analogues, and dual GLP-1/GIP agonist
Assessment of weight-loss potential and adverse events
Traditional drugs show modest weight-loss potential and higher adverse event risks
Naltrexone-bupropion offers greater efficacy and central appetite regulation benefits
GLP-1 analogues like liraglutide and semaglutide enable approximately 16% weight reduction
Tirzepatide shows potential for even greater weight loss
Future treatments may focus on multireceptor therapies tailored to individual patients

Plinta et al. (2026) studied this question.

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