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February 7, 2026

Evaluating C-Reactive Protein in Drainage Fluid as a Predictive Biomarker for Clinically Relevant Pancreatic Fistulas Following Pancreaticoduodenectomy.

Kenta Baba Kenichiro Uemura Tatsuaki Sumiyoshi Ryuta Shintakuya K. Okada Takumi Harada Shiro Oka Yasutaka Ishii Koji Arihiro Yoshiaki Murakami Shinya Takahashi

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Key Points

This research aims to determine if C-reactive protein levels in drainage fluid can predict clinically relevant pancreatic fistulas after surgery.
Evaluated C-reactive protein levels in drainage fluid on postoperative day 4.
Compared drain CRP levels with serum CRP levels.
Assessed the occurrence of clinically relevant pancreatic fistulas (CR-POPFs).
Drain CRP levels on postoperative day 4 are strong predictors of CR-POPFs.
Drainage fluid CRP may serve as an alternative to serum CRP levels.

Implication

Observational study finds drain CRP levels predict pancreatic fistulas after pancreaticoduodenectomy, suggesting a new criterion for assessment.

Abstract

Drain CRP level on POD 4 is a strong predictive factor for CR-POPFs and may be an alternate criterion to serum CRP levels after PD.

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Cite This Study

Baba et al. (2026) studied this question.

synapsesocial.com/papers/698acaf07c832249c30baa59 https://doi.org/10.1245/s10434-026-19140-z

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Postoperative Day 3 Biomarkers for Risk Stratification and Prediction of Clinically Relevant Pancreatic Fistula After Pancreaticoduodenectomy: A Retrospective Cohort StudyCohort Study · 2026
2C-Reactive Protein Levels Can Predict Post-Operative Pancreatic Fistula (POPF) Formation After Pancreatic Resections2024
3The critical 18 of postoperative white blood cells and C-reactive protein predicts postoperative pancreatic fistula after distal pancreatectomy2025
4“The Critical 18” of postoperative white blood cell count and C-reactive protein level predicts postoperative pancreatic fistula after distal pancreatectomyCohort Study · 2026
5Dynamic Assessment of Drain Fluid Amylase Estimates the Risk of CR-POPF Following Pancreatoduodenectomy2024 · 3 citations

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