What does this research mean for the field?

Measuring serum lipase on postoperative day 3, particularly in combination with procalcitonin, accurately predicts and excludes clinically relevant pancreatic fistula after pancreaticoduodenectomy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the predictive accuracy and optimal timing of serum lipase, alone and combined with procalcitonin, for detecting clinically relevant pancreatic fistula after pancreaticoduodenectomy.

September 3, 2026CancersOpen Access

Optimal Timing of Serum Lipase for Early Prediction of Clinically Relevant Pancreatic Fistula After Pancreaticoduodenectomy

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Authors

RCRoberto CammarataUniversità Campus Bio-Medico LCL. CarboneUniversity of Siena VVVincenzo La VaccaraCampus Bio Medico University Hospital

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Implication

Cohort study reveals postoperative day 3 serum lipase predicts pancreatic fistula after pancreaticoduodenectomy, highlighting enhanced risk stratification when combined with procalcitonin.

Key Points

To assess the predictive accuracy and optimal timing of serum lipase, alone and combined with procalcitonin, for detecting clinically relevant pancreatic fistula after pancreaticoduodenectomy.
Conducted a single-center study evaluating 115 patients who underwent pancreaticoduodenectomy between 2015 and 2019.
Measured serum lipase preoperatively and on postoperative days (POD) 1, 2, and 3, defining elevation as >3× the institutional upper limit of normal (>177 U/L).
Serum lipase was higher in patients with clinically relevant pancreatic fistula across all postoperative days (p < 0.01), with AUC increasing from 0.76 (POD 1) to 0.82 (POD 2 and POD 3) and specificity improving from 52.7% to 89.2% (negative predictive value 92.5–93.3%).
Elevated serum lipase on POD 3 significantly predicted clinically relevant pancreatic fistula (OR 6.89, 95% CI 1.61–29.53; p = 0.009).
Combining elevated serum lipase with procalcitonin ≥ 1.5 ng/mL on POD 3 achieved 100% specificity for predicting fistula development.

Cite This Study

Cammarata et al. (2026) studied this question.

synapsesocial.com/papers/6a993600636c6408cfa7ec89 https://doi.org/10.3390/cancers18172821

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Implication

Cohort study reveals postoperative day 3 serum lipase predicts pancreatic fistula after pancreaticoduodenectomy, highlighting enhanced risk stratification when combined with procalcitonin.

Optimal Timing of Serum Lipase for Early Prediction of Clinically Relevant Pancreatic Fistula After Pancreaticoduodenectomy

Discussion

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Implication

Key Points

Cite This Study

Optimal Timing of Serum Lipase for Early Prediction of Clinically Relevant Pancreatic Fistula After Pancreaticoduodenectomy

Discussion

Member takes

Implication

Key Points

Cite This Study

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