Development and validation of prognostic nomograms based on peripheral blood T-cell counts and their dynamic changes for patients with nasopharyngeal carcinoma receiving radiotherapy

Kegui Weng; Qianqian Lei; Ye Hong; Kaihua Chen; Sun Ying; Ying Wang; Xiaodong Zhu

doi:10.1016/j.tranon.2025.102661

February 7, 2026Translational OncologyOpen Access

Development and validation of prognostic nomograms based on peripheral blood T-cell counts and their dynamic changes for patients with nasopharyngeal carcinoma receiving radiotherapy

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Key Points

The study aims to develop and validate prognostic nomograms using peripheral blood T-cell counts for nasopharyngeal carcinoma patients receiving radiotherapy.
Developed nomograms based on T-cell counts and their dynamic changes.
Validated the nomograms in an external cohort.
Compared prognostic accuracy with conventional staging systems.
Nomograms reliably predicted progression-free survival (PFS) and overall survival (OS).
Improved prognostic discrimination beyond traditional staging methods.

Implication

Nomograms predict prognosis in nasopharyngeal carcinoma patients undergoing radiotherapy, suggesting improved individual risk assessment.

Abstract

The proposed T-cell-based nomograms reliably predict PFS and OS in patients with NPC undergoing radiotherapy and were validated in an external cohort. These models provide improved prognostic discrimination beyond conventional staging systems and may assist in individualized risk stratification and management planning.

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Cite This Study

Weng et al. (2026) studied this question.

synapsesocial.com/papers/698c1bb8267fb587c655d8da https://doi.org/10.1016/j.tranon.2025.102661

View Full Paper

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Development and validation of prognostic nomograms based on peripheral blood T-cell counts and their dynamic changes for patients with nasopharyngeal carcinoma receiving radiotherapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Development and validation of prognostic nomograms based on peripheral blood T-cell counts and their dynamic changes for patients with nasopharyngeal carcinoma receiving radiotherapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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