Preclinical models show electrophysiologic signals from spinal cord stimulation may reflect processing and efficacy, suggesting usefulness as biomarkers.
This study outlines electrophysiologic signals evoked by SCS in terms of their waveform, recruitment thresholds, and putative physiologic origins. We propose that to some extent, these signals reflect different aspects of spinal processing and may serve as biomarkers of dysregulated nociceptive pathways, and as indicators of SCS efficacy or potential side effects.
No takes yet. Share an insight, caveat, or question.
Ladner et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: