Genome-wide reconstruction of the intrinsic apoptosis pathway in Haemonchus contortus

Yanxiang Shen; Neil D. Young; Jiangning Song; Brad E. Sleebs; Bill C. H. Chang; Erinna F. Lee; W. Douglas Fairlie; Robin B. Gasser

doi:10.1186/s12864-026-12596-z

February 9, 2026BMC GenomicsOpen Access

Genome-wide reconstruction of the intrinsic apoptosis pathway in Haemonchus contortus

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study aims to reconstruct the intrinsic apoptosis pathway in Haemonchus contortus to elucidate its structural and regulatory features.
Conducted genome-wide analysis of Haemonchus contortus
Identified conserved structural features of apoptosis
Examined developmental regulation of apoptosis
Defined a comprehensive molecular framework of the intrinsic apoptosis pathway
Highlighted key apoptotic regulators for further functional studies
Provided potential targets for developing new anthelmintic treatments

Ask about this paper

Answers are grounded in this paper and cite their sources.

Abstract

This molecular framework highlights conserved structural features and developmental regulation of apoptosis in a parasitic nematode and provides a basis for functional studies to evaluate apoptotic regulators as potential targets for anthelmintic development.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Shen et al. (2026) studied this question.

synapsesocial.com/papers/698c1bcd267fb587c655daca https://doi.org/10.1186/s12864-026-12596-z

View Full Paper

Ask AI

Bookmark

Share

Genome-wide reconstruction of the intrinsic apoptosis pathway in Haemonchus contortus

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

Genome-wide reconstruction of the intrinsic apoptosis pathway in Haemonchus contortus

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

Keep reading

Keep reading