Visible-light-mediated nickel-catalyzed C(sp3)–C(sp3) coupling in α-bromonitriles indicates significant synthetic utility.
We report a visible-light-mediated nickel-catalyzed C(sp³)-C(sp³) cross-coupling between α-bromonitriles and alkylzirconocene reagents enabled by a direct photoexcitation strategy. Alkyl radicals are generated from in situ formed alkylzirconocenes under visible-light irradiation and efficiently incorporated into a nickel catalytic cycle to forge C(sp³)-C(sp³) bonds under mild conditions. The reaction accommodates a range of α-bromonitriles and alkene-derived alkyl fragments, and its synthetic utility is demonstrated by scale-up experiments and downstream derivatizations.
No takes yet. Share an insight, caveat, or question.
Xie et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: