What question did this study set out to answer?

This review examines whether bone metabolism biomarkers fluctuate during the menstrual cycle in healthy females.

Understanding Bone Metabolism Biomarker Variability Across the Menstrual Cycle: A Systematic Review

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Systematic review evaluates bone biomarkers in healthy menstruating females, highlighting inconsistencies and variability.

This review examines whether bone metabolism biomarkers fluctuate during the menstrual cycle in healthy females.
Conducted a systematic review following PRISMA guidelines.
Searched databases PubMed and Web of Science.
Included 18 studies assessed for quality using the NHLBI tool.
Analyzed biomarkers such as β-CTX-I and osteocalcin across menstrual phases.
5 out of 7 studies found lower β-CTX-I levels during the luteal phase.
6 out of 8 studies indicated no variation in osteocalcin across the menstrual cycle.
Overall, findings on other biomarkers were limited and inconsistent.

Guisado-Cuadrado et al. (2026) studied this question.

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