Effect of Mitophagy on the Tension-Driven Osteogenic Differentiation of Periodontal Ligament Stem Cells During Ageing

Chuhan Peng; Yidan Zhang; Linna Bai; Xinyu Zhang; Bowen Xu; Kun Yang

doi:10.1016/j.identj.2026.109408

February 9, 2026International Dental JournalOpen Access

Effect of Mitophagy on the Tension-Driven Osteogenic Differentiation of Periodontal Ligament Stem Cells During Ageing

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Key Points

The research aims to explore how mitophagy affects the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) under tension during ageing.
Examined the role of mitophagy in PDLSCs under tension conditions.
Analyzed osteogenic differentiation markers in PDLSCs.
Investigated age-related differences in mitophagy activity in PDLSCs.
Mitophagy enhances osteogenic differentiation in PDLSCs when subjected to tension.
Age affects the efficiency of mitophagy in PDLSCs, suggesting changes in differentiation ability over time.

Implication

Demonstrates the role of mitophagy in osteogenic differentiation in periodontal ligament stem cells, suggesting a link to age-related changes.

Abstract

Mitophagy is associated with osteogenic activity induced by tension force in PDLSCs and may play a substantial role in regulating age-related changes in the OTM process.

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Cite This Study

Peng et al. (2026) studied this question.

synapsesocial.com/papers/698c1c33267fb587c655e685 https://doi.org/10.1016/j.identj.2026.109408

View Full Paper

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Effect of Mitophagy on the Tension-Driven Osteogenic Differentiation of Periodontal Ligament Stem Cells During Ageing

Key Points

Implication

Abstract

Discussion

Cite This Study

Effect of Mitophagy on the Tension-Driven Osteogenic Differentiation of Periodontal Ligament Stem Cells During Ageing

Key Points

Implication

Abstract

Discussion

Cite This Study

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